Hydrogen Effect on Organs

Hydrogen gas and hydrogen-rich water have been found to be effective in promoting brain health and function. Research has shown that hydrogen has antioxidant and anti-inflammatory effects in the brain, which can help protect against neurodegenerative diseases such as Alzheimer's and Parkinson's. Hydrogen gas has been shown to improve cognitive function in animal models of Alzheimer's disease. In one study, mice with Alzheimer's disease were exposed to hydrogen gas for one hour a day for four weeks. The results showed that the mice had improved cognitive function and reduced levels of oxidative stress in the brain. Hydrogen-rich water has also been found to have beneficial effects on the brain. In a study of healthy adults, drinking hydrogen-rich water for four weeks was found to improve cognitive function and reduce oxidative stress in the brain. In addition to its antioxidant and anti-inflammatory properties, hydrogen has also been found to have anti-apoptotic effects in the brain. Apoptosis is a process of programmed cell death that can occur in the brain as a result of injury or disease. By inhibiting apoptosis, hydrogen may help protect brain cells from damage and promote brain health. Overall, the evidence suggests that hydrogen gas and hydrogen-rich water may be effective in promoting brain health and function. While more research is needed to fully understand the mechanisms of action and potential benefits, these findings are promising and suggest that hydrogen may be a natural and safe approach to supporting brain health.

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Nakano T, Kotani T, Imai K, Iitani Y, Ushida T, Tsuda H, Li H, Iwase A, Toyokuni S, Kikkawa F. Effect of molecular hydrogen on uterine inflammation during preterm labour. Biomed Rep. 2018 May;8(5):454-460. doi: 10.3892/br.2018.1082. Epub 2018 Mar 27. PMID: 29732148; PMCID: PMC5920961.


Matsumoto S, Ueda T, Kakizaki H. Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome. Urology. 2013 Feb;81(2):226-30. doi: 10.1016/j.urology.2012.10.026. PMID: 23374763.


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Shin DW, Yoon H, Kim HS, Choi YJ, Shin CM, Park YS, Kim N, Lee DH. Effects of Alkaline-Reduced Drinking Water on Irritable Bowel Syndrome with Diarrhea: A Randomized Double-Blind, Placebo-Controlled Pilot Study. Evid Based Complement Alternat Med. 2018 Apr 15;2018:9147914. doi: 10.1155/2018/9147914. PMID: 29849734; PMCID: PMC5925025.


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Da Ponte A, Giovanelli N, Nigris D, Lazzer S. Effects of hydrogen rich water on prolonged intermittent exercise. J Sports Med Phys Fitness. 2018 May;58(5):612-621. doi: 10.23736/S0022-4707.17.06883-9. Epub 2017 Apr 26. PMID: 28474871.


Tao B, Liu L, Wang N, Wang W, Jiang J, Zhang J. Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs. J Surg Res. 2016 May 15;202(2):291-8. doi: 10.1016/j.jss.2016.01.009. Epub 2016 Jan 14. PMID: 27229103.


Guo SX, Fang Q, You CG, Jin YY, Wang XG, Hu XL, Han CM. Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation. J Transl Med. 2015 Jun 6;13:183. doi: 10.1186/s12967-015-0548-3. PMID: 26047940; PMCID: PMC4467622.


Yan WM, Zhang L, Chen T, Zhao GH, Long P, An J, Zhang ZM. Effects of hydrogen-rich saline on endotoxin-induced uveitis. Med Gas Res. 2017 Mar 30;7(1):9-18. doi: 10.4103/2045-9912.202905. PMID: 28480027; PMCID: PMC5402351.


Wang W, Tian L, Li Y, Wang X, Xia F, Li L, Li J, Zhang Z. Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning. J Emerg Med. 2013 Jan;44(1):107-15. doi: 10.1016/j.jemermed.2012.01.065. Epub 2012 Aug 14. PMID: 22897968.  


Zhang DQ, Feng H, Chen WC. Effects of hydrogen-rich saline on taurocholate-induced acute pancreatitis in rat. Evid Based Complement Alternat Med. 2013;2013:731932. doi: 10.1155/2013/731932. Epub 2013 Jul 28. PMID: 23983797; PMCID: PMC3745843.  


Li GM, Ji MH, Sun XJ, Zeng QT, Tian M, Fan YX, Li WY, Li N, Yang JJ. Effects of hydrogen-rich saline treatment on polymicrobial sepsis. J Surg Res. 2013 May;181(2):279-86. doi: 10.1016/j.jss.2012.06.058. Epub 2012 Jul 7. PMID: 22795273.  


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Takeuchi S, Mori K, Arimoto H, Fujii K, Nagatani K, Tomura S, Otani N, Osada H, Wada K. Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial. BMC Neurol. 2014 Sep 9;14:176. doi: 10.1186/s12883-014-0176-1. PMID: 25201463; PMCID: PMC4172868.


Nishimaki K, Asada T, Ohsawa I, Nakajima E, Ikejima C, Yokota T, Kamimura N, Ohta S. Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Curr Alzheimer Res. 2018 Mar 14;15(5):482-492. doi: 10.2174/1567205014666171106145017. PMID: 29110615; PMCID: PMC5872374.


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