Hydrogen Effects

Hydrogen in Bones

Hydrogen-rich water is a type of water that is rich in molecular hydrogen. It has been suggested that drinking hydrogen-rich water has a number of health benefits, including improving bone health. Studies have shown that hydrogen-rich water can help reduce oxidative stress in the body, which can lead to improved bone health. Oxidative stress is a condition in which there is an imbalance between the production of reactive oxygen species (ROS) and the body's ability to detoxify them. ROS can damage cells and tissues, including bone tissue, leading to bone loss and osteoporosis. Hydrogen-rich water has antioxidant properties that can help neutralize ROS and reduce oxidative stress in the body. This can help protect bone tissue from damage and promote bone health. In addition to reducing oxidative stress, hydrogen-rich water has also been shown to have anti-inflammatory properties. Inflammation is a major contributor to bone loss and osteoporosis. By reducing inflammation, hydrogen-rich water may help prevent bone loss and promote bone health. Overall, while more research is needed to fully understand the benefits of hydrogen-rich water on bones, the current evidence suggests that it may be a promising natural approach to improving bone health. Drinking hydrogen-rich water may be a simple and effective way to support bone health and prevent conditions such as osteoporosis.

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Lee J, Yang G, Kim YJ, Tran QH, Choe W, Kang I, Kim SS, Ha J. Hydrogen-rich medium protects mouse embryonic fibroblasts from oxidative stress by activating LKB1-AMPK-FoxO1 signal pathway. Biochem Biophys Res Commun. 2017 Sep 23;491(3):733-739. doi: 10.1016/j.bbrc.2017.07.119. Epub 2017 Jul 22. PMID: 28743498.  

Xu F, Yu S, Qin M, Mao Y, Jin L, Che N, Liu S, Ge R. Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-β in Guinea Pigs. Inflammation. 2018 Feb;41(1):81-92. doi: 10.1007/s10753-017-0666-6. PMID: 28894978.  

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Hu Z, Wu B, Meng F, Zhou Z, Lu H, Zhao H. Impact of molecular hydrogen treatments on the innate immune activity and survival of zebrafish (Danio rerio) challenged with Aeromonas hydrophila. Fish Shellfish Immunol. 2017 Aug;67:554-560. doi: 10.1016/j.fsi.2017.05.066. Epub 2017 Jun 16. PMID: 28630014.  

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Ge Y, Wu F, Sun X, Xiang Z, Yang L, Huang S, Lu Z, Sun Y, Yu WF. Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats. PLoS One. 2014 May 23;9(5):e97436. doi: 10.1371/journal.pone.0097436. Erratum in: PLoS One. 2014;9(9):e109482. PMID: 24857932; PMCID: PMC4032255.

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Li J, Wu X, Chen Y, Zeng R, Zhao Y, Chang P, Wang D, Zhao Q, Deng Y, Li Y, Alam HB, Chong W. The Effects of Molecular Hydrogen and Suberoylanilide Hydroxamic Acid on Paraquat-Induced Production of Reactive Oxygen Species and TNF-α in Macrophages. Inflammation. 2016 Dec;39(6):1990-1996. doi: 10.1007/s10753-016-0434-z. PMID: 27624060.  

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Zhao J, Zhang M, Li Y, Zhang Z, Chen M, Liu T, Zhang J, Shan A. Therapeutic Effect of Hydrogen Injected Subcutaneously on Onion Poisoned Dogs. J Vet Res. 2017 Dec 27;61(4):527-533. doi: 10.1515/jvetres-2017-0068. PMID: 29978119; PMCID: PMC5937354. Therapeutic Effect of Hydrogen Injected Subcutaneously on Onion Poisoned Dogs.

Zhao S, Mei K, Qian L, Yang Y, Liu W, Huang Y, Zhang C, Sun X, Liu C, Li B, Gao F, Cai J, Ni J. Therapeutic effects of hydrogen-rich solution on aplastic anemia in vivo. Cell Physiol Biochem. 2013;32(3):549-60. doi: 10.1159/000354459. Epub 2013 Aug 30. PMID: 24008771.  

Chen Y, Chen H, Xie K, Liu L, Li Y, Yu Y, Wang G. H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation. 2015 Oct;38(5):1835-46. doi: 10.1007/s10753-015-0161-x. PMID: 25820467.

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